E-learning is a new training tool to reduce time and cost. Despite the e-learning successes have been widely studied, the critical factors affect employees’ satisfaction toward e-learning still remained unclear. This study suggests qualities, facilitating conditions, and technology acceptances are three major dimensions associate users’satisfaction. We also argue that the social influence moderates the influences. A survey from two largest companies in Taiwan of different industries was performed to investigate the validation of the proposed model. The results not only confirm the effects of critical dimensions, but also verify social influence moderating some of the factors to users’ satisfaction. To establish an effective e-learning system, higher levels of perceived qualities, facilitating conditions, technology acceptances, and social influence are required to achieve a higher level of satisfaction. The theoretical and practical implications of this study demonstrate the effects of research constructs with regard to satisfaction with e-learning systems.