Meiho University Institutional Repository:Item 987654321/1657
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    Please use this identifier to cite or link to this item: http://ir.meiho.edu.tw/ir/handle/987654321/1657


    Title: 中草藥抑制B型肝炎病毒作用之研究
    Authors: 黃瑞齡;施慧娟;陳春香
    Contributors: 健康暨護理學院
    Date: 2011
    Issue Date: 2012-06-27T06:54:54Z (UTC)
    Abstract: B型肝炎是國人常見的肝臟疾病,會引起急性及慢性肝炎,慢性肝炎患者長期染病,極易轉為猛暴性肝炎、肝硬化及肝癌。
    本產學計畫以體外細胞培養模式,利用酵素連結免疫吸附分析法(Enzyme-Linked Immunosorbent Assay) 測定葡萄王生技股份有限公司提供之十種中草藥萃取物,對人類B型肝炎病毒野生型及lamivudine抗藥性突變株於病毒表面抗原及e抗原之作用。0.25% DMSO組為solvent control,無細胞毒性,對HBV野生型及拉美夫錠抗藥性突變株之表面抗原和e抗原均無抑制作用。分離自獨活的 Osthole為正對照組,Osthole 給藥濃度80 M對HBV野生型之表面抗原具強度抑制(+++)其抑制百分比為50.1  2.3,對拉美夫錠抗藥性突變株之表面抗原具強度抑制(+++)其抑制百分比為52.9  3.0對HBV野生型及拉美夫錠抗藥性突變株之e抗原均無顯著抑制作用。GK-Lr-W-Me25、GK-Lr-W-HW25、GK-Lr-M-Me25、GK-Lr-M-HW25、MAL-Lr-SCL-Me25、MAL-Lr-SCL-HW25、MAL-Lr-M- Me25、MAL-Lr-M-HW25、MAL-Lr-SCL-CA及WT-Lr-SCL-HW20等10個供測樣品,對HBV野生型及拉美夫錠抗藥性突變株之表面抗原和e抗原均無抑制作用。
    Appears in Collections:[Department of Biological Science and Technology] Research Projects

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