In a rapidly changing business environment, IT professionals not only have to keep abreast of technological knowledge, but also take the responsibility for roles that are more entrepreneurial in nature and focus more on innovation through IT. This study proposed a new concept of business technology management (BTM) competency to explore the associated knowledge and skills, and examined the validity of the nomological framework. The empirical data in general supported the proposed competency model of BTM and revealed that business domain knowledge, IT-business integration, as well as management, interpersonal skills and knowledge contribute significantly to IT professionals’ proficiencies on their BTM competency. The results of this study, therefore, can provide useful principles to help IT professionals review business technology management proficiencies and may serve as instrumental guidelines for the BTM competency training to strengthen IT-business relationship building