資料載入中.....
|
請使用永久網址來引用或連結此文件:
http://ir.meiho.edu.tw/ir/handle/987654321/1793
|
| 題名: | Uric acid level as a risk marker for metabolic syndrome: A Chinese cohort study |
| 作者: | Yanga, Tsan;Chub, Chi-Hong;Baic, Chyi-Huey;San-Lin Youd, e;Choue, Yu-Ching;Chouf, Wan-Yun;Chieng, Kuo-Liong;Hwangh, Lee-Ching;Sui, Ta-Chen;Tsengi, Chin-Hsiao;Sunf, Chien-An |
| 關鍵詞: | Cohort study;Hyperuricemia;Metabolic syndrome;Uric acid |
| 日期: | 2012-02 |
| 上傳時間: | 2012-09-21T01:41:48Z (UTC)
|
| 摘要: | Objective: Despite some epidemiologic research demonstrating a positive relationship between serum uric acid (SUA) levels and the prevalence of metabolic syndrome (MetS), prospective data on SUA as a predictor of MetS incidence are limited.
Methods: The authors examined SUA as a risk marker for incident MetS in a prospective study of 3857 subjects who were free of MetS at baseline recruitment. Hyperuricemia was defined as SUA ≥7.7 mg/dL for men and ≥6.6 mg/dL for women. The MetS was defined according to a unified criteria set by several major organizations.
Results: During a mean follow-up of 5.41 years, 476 participants developed MetS. A significantly stepwise increase in the incidence of MetS across tertiles of SUA was observed in the whole group (p for trend <0.001). Among women, this association was more robust than in men. After adjustment for age, variations of blood pressure, triglycerides, HDL-C, glucose, and waist circumference, females in the middle and upper tertiles of SUA had significantly higher risk of developing MetS when compared with subjects in the lowest tertile [adjusted-HR (95% CI) was 1.67 (1.12–2.49) and 3.18 (2.20–4.60), respectively; p for trend <0.001]. Overall, hyperuricemia was a significantly independent risk determinant for MetS in women, but it was a non-significant factor for MetS mediating waist circumference and serum triglycerides in men.
Conclusion: SUA concentration is more closely associated with MetS in females than in males. Future investigations are needed to explore the underlying mechanisms involved in the sex-related association between SUA concentration and MetS risk. |
| 關聯: | Atherosclerosis Volume 220, Issue 2, February 2012, Pages 525–531 |
| 顯示於類別: | [健康事業管理系 ] 期刊論文
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| Uric acid level as a risk marker for metabolic syndrome-A Chinese cohort study.pdf | Uric acid level as a risk marker for metabolic syndrome: A Chinese cohort study | 401Kb | Adobe PDF | 1 | 檢視/開啟 | | index.html | Uric acid level as a risk marker for metabolic syndrome: A Chinese cohort study | 0Kb | HTML | 633 | 檢視/開啟 |
|
在MUIR中所有的資料項目都受到原著作權保護.
|
