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    Please use this identifier to cite or link to this item: http://ir.meiho.edu.tw/ir/handle/987654321/1807


    Title: Evaluation of the antioxidative capability of commonly used antioxidants in dermocosmetics by in vivo detection of protein carbonylation in human stratum corneum
    Authors: Feng-Jen Tsai;Yuan-Dai Wang;Cheng-Chi Chen;Chen Hsieh;Zhi-Jiao Cheng;Yu-Jen Wu
    Contributors: 健康暨護理學院
    Date: 2012
    Issue Date: 2012-09-25T03:04:06Z (UTC)
    Abstract: We present an in vivo test platform to evaluate the antioxidative capability of seven frequently used
    dermocosmetic antioxidants on the human stratum corneum (SC). It has been reported that the protein
    carbonylation could be used as a biomarker for oxidative stress. The current study detects the change of
    the level of exposed protein carbonyl group in the most outer layer of human SC. The concentration of the
    antioxidant in each subject emulsion formulation was 0.5% (w/w). The data indicated that alpha-tocopherol
    (a-Vit E) and ascorbic acid (Vit C) have excellent antioxidative capability and a-Vit E-acetate possesses
    better than the average antioxidative capability. The bioconversion of a-Vit E-acetate to a-Vit E
    may occur in the human SC during a less than 2 weeks time course test. Lipoic acid possessed moderate
    antioxidative capability. Ascorbyl 6-palmitate had a low antioxidative capability. Ascorbic acid 2-glucoside
    represented an insignificant antioxidative capability. Glutathion (GSH) had no effect on reducing oxidative
    damage to human SC proteins, implying that the GSH recycling system could be absent in human
    SC. This test platform is an useful tool to evaluate the antioxidative efficiency of antioxidants on human
    SC proteins.
    Appears in Collections:[Department of Beauty Science] Papers

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