Meiho University Institutional Repository:Item 987654321/2160
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 2876/3793 (76%)
Visitors : 3859706      Online Users : 541
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.meiho.edu.tw/ir/handle/987654321/2160


    Title: Pseudallin, a new antibiotic produced by the human pathogenic fungus Pseudallescheria boydii, with ecological significance
    Authors: Pseudallin, a new antibiotic produced by the human pathogenic fungus Pseudallescheria boydii, with ecological significance
    Keywords: Alternaria brassicicola;Antibiotic;Black leaf spot;Human pathogen;Plant disease control;Pseudallescheria boydii;Pseudallin
    Date: 2012
    Issue Date: 2013-10-03T02:58:37Z (UTC)
    Abstract: Pseudallescheria boydii is an emerging fungal human pathogen causing serious disease in both
    immunocompromised and immunocompetent patients. Recent report showed that this fungus is capable of
    controlling black leaf spot of cabbage caused by Alternaria brassicicola by producing a fungistatic substance
    strongly inhibitory to fungi. Production of the inhibitory substance by P. boydii during colonization of plant
    tissues in soil appears to account for its strong competitive saprophytic ability and widespread occurrence in soil. In this study, freeze-dried powder of liquid culture of P. boydii was extracted with ethanol and fractionated on silica gel column to give four fractions. The most active fraction was further purified by silica gel chromatography. The resulting compound 1 was structurally characterized as 6-6’-bis (2H-pyran-3-carbaldehyde) ether which is a new natural product showing strong inhibitory activity against A. brassicicola. The new antibiotic, a yellow oil with a molecular weight of 234, was named pseudallin. To our knowledge, this is the first report of antibiotic production by a non-dermatophyte human pathogenic fungus. Results from this study indicate the importance of antibiotic production in competitive saprophytic colonization of plant debris by P.boydii in soil, which in turn may explain its widespread occurrence.
    Relation: Botanical Studies (2012) 53: 239-24 2.
    Appears in Collections:[Department of Nursing] Papers

    Files in This Item:

    File Description SizeFormat
    Bot532-08.pdffulltext494KbAdobe PDF0View/Open


    View Licence

    All items in MUIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback