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| 題名: | Eugenosedin-A prevents high-fat diet increased adhesionmolecules through inhibition of MAPK- and p65-mediatedNF-kB pathway in rat model |
| 作者: | Lina, Hui-Li;Shenb, Kuo-Ping;Changc, Wen-Tsan;Lind, Jou-Chun;Ane, Li-Mei;Chene, Ing-Jun;Wu, Bin-Nan |
| 貢獻者: | 健康暨護理學院 |
| 日期: | 2012 |
| 上傳時間: | 2013-11-07T07:40:28Z (UTC)
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| 摘要: | Objectives Previous studies have shown eugenosedin-A, a 5-HT1B/2A and a1/a2/b1-
adrenergic blocker, is able to decrease cholesterol levels, hyperglycaemia and
inflammation in hyperlipidaemic mice induced by high-fat diet (HFD). The aim
of this study is to examine the effects of eugenosedin-A on the inhibition of
adhesion molecules of platelets, the aorta and acyl-coenzymeA:cholesterol
acyltransferase-1 (ACAT-1) of macrophages in a hyperlipidaemic rat model.
Methods Six-week-old Sprague–Dawley rats were randomly divided into two
control and treatment groups. The control rats received either a regular diet or
HFD and the treatment groups were fed HFD with either 5 mg/kg eugenosedin-A
or atorvastatin for a 10-week period.
Key findings Compared with the two control groups, the HFD group had lower
levels of high-density lipoprotein, higher concentrations of triglycerides, total cholesterol,
low-density lipoprotein and insulin. The expression of adhesion molecules
in platelets, aorta and monocyte-macrophage were enhanced by HFD. HFD
also increased upstream proteins and their phosphorylated form in the aorta. In
treatment groups, eugenosedin-A and atorvastatin improved HFD-induced
hyperlipidaemia and levels of insulin. Eugenosedin-A reduced the upregulation of
P-selectin, ICAM-1, ICAM-2, ICAM-3, VCAM, PECAM in platelets and inhibited
E-selectin, ICAM-1, ICAM-2, ICAM-3, VCAM and PECAM protein levels in the
aorta. Eugenosedin-A reduced the ACAT-1 protein expression of monocytemacrophages.
The expression of PKCa, MAPKs, IKKa and p65 and their phosphorylated
form were reduced in treatment groups.
Conclusions Taken together, hyperlipidaemia enhances the expression of adhesion
molecules and ACAT-1 protein, and eugenosedin-A ameliorates those
increases. Through inhibition of MAPK- and p-65-mediated NF-kB pathway,
eugenosedin-A decreases the quantity of adhesion molecules. |
| 關聯: | Journal of Pharmacy And Pharmacology |
| 顯示於類別: | [食品營養系] 期刊論文
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| JPP 2013[1].pdf | | 778Kb | Adobe PDF | 1607 | 檢視/開啟 |
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