探討養殖軟珊瑚中sinulariolide 對肝癌細胞抗腫瘤及分子機制之研究;Investigation of Anti-Tumor Activities and Molecular Mechanism of sinulariolide From The Cultured Soft Corals Sinularia flexibilis on Hepatoma Cells

MUIR > Seminar > 2013 International Conference on Health Care and Health Industry > Item 987654321/2428

Please use this identifier to cite or link to this item: http://ir.meiho.edu.tw/ir/handle/987654321/2428

Title:	探討養殖軟珊瑚中sinulariolide 對肝癌細胞抗腫瘤及分子機制之研究;Investigation of Anti-Tumor Activities and Molecular Mechanism of sinulariolide From The Cultured Soft Corals Sinularia flexibilis on Hepatoma Cells
Authors:	曹家毓;林振頡;吳裕仁;廖明輝
Keywords:	肝癌;sinulariolide;細胞凋亡
Date:	2013
Issue Date:	2014-04-21T08:46:36Z (UTC)
Abstract:	sinulariolide，從軟珊瑚Sinularia flexibilis 的一個分離的化合物，具有抗HA22T 肝癌細胞的增殖能力，抗遷移和誘導細胞凋亡活性。分別採用MTT 法，細胞遷移實驗和流式細胞儀測定sinulariolide 的抗腫瘤作用。 sinulariolide 以劑量依賴的方式抑制肝癌細胞的生長和遷移，以及誘導流式細胞儀測定凋亡的早期和晚期。sinulariolide 誘導細胞凋亡相關的線粒體介導的細胞凋亡是藉由caspase 依賴的途徑，闡明線粒體膜電位的損失，釋放細胞色素C，激活caspase-3/-9，Bax 和Bad 抑制Bcl-2/Bcl-xL/Mcl-1。 PARP-1 cleaved 部分產物參與caspase-independent 途徑。
Appears in Collections:	[Seminar] 2013 International Conference on Health Care and Health Industry

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