Metabolic syndrome and C-reactive protein concentration as independent correlates of chronic kidney disease

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Please use this identifier to cite or link to this item: http://ir.meiho.edu.tw/ir/handle/987654321/2476

Title:	Metabolic syndrome and C-reactive protein concentration as independent correlates of chronic kidney disease
Authors:	Tsan Yang;Yu-Ching Chou;Chi-Hong Chu;Shih-Hua Lin;Po-Chien Hsieh;Chih-Hsung Hsu;Chyi-Huey Bai;San-Lin You;Chien-An Sun
Keywords:	Chronic kidney disease;C-reactive protein;inflammation;metabolic syndrome
Date:	2014
Issue Date:	2014-09-02T02:29:05Z (UTC)
Abstract:	Inflammation is a common phenotype for cardiometabolic disorders. In this study, we attemptedto investigate inter-relationships between metabolic syndrome (MetS), C-reactive protein (aninflammatory biomarker) and chronic kidney disease (CKD). We performed a cross-sectionalanalysis of data from a representative sample of 4425 Chinese adults in Taiwan. The MetS wasdefined by a unified criteria set by several major organizations. A CKD event was defined as anestimated glomerular filtration rate (eGFR)560 mL/min per 1.73m2. Additionly, a CRP cutpoint of3 mg/L was used to differentiate high and low CRP levels. Overall, 1000 participants had MetS,resulting in a prevalence rate of 22.6%. High CRP level was noted in 782 (17.6%) subjects. Inaddition, a total of 508 (11.5%) persons qualified as having CKD. Subjects with the MetS had 1.55-fold [95% confidence interval (CI), 1.03–2.32] increased odds of CKD compared with theircounterparts without the MetS after multiple adjustments. In addition, there was a significantlygraded relationship between increasing levels of serum CRP and prevalent CKD (p fortrend¼0.001). Participants in the highest category of serum CRP had a significantly elevatedodds of CKD as compared with those in the lowest category [odds ratio (OR), 1.60; 95% CI, 1.21–2.12]. However, there was no interaction in excess of additive scale between the presence of MetSand high CRP level (p¼0.83). These findings suggest that MetS and high CRP wereindependently associated with increased prevalence of CKD in Chinese adults.
Relation:	Endocr Res, 2014; 39(3): 94–98
Appears in Collections:	[Department of Health Business Administration] Papers

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