The Flavonoids in Citrus madurensis Lour and their Anti-Hepatitis B Virus Activity

MUIR > Graduate Institute of Health Care > Department of Biological Science and Technology > Papers > Item 987654321/2540

Please use this identifier to cite or link to this item: http://ir.meiho.edu.tw/ir/handle/987654321/2540

Title:	The Flavonoids in Citrus madurensis Lour and their Anti-Hepatitis B Virus Activity
Authors:	Pei-Hsin Shie;Ray-Ling Huang;Horng-Liang Lay
Contributors:	健康暨護理學院
Keywords:	Citrus madurensis Lour;Citrus flavonoids
Date:	2013
Issue Date:	2014-09-16T06:58:09Z (UTC)
Abstract:	Citrus madurensis Lour. (calamondin), a perennial tree in the family Rutaceae, is a important citrus tree in Taiwan where its juice and fruit are popular among consumers. However, juice production often results in a considerable amount of waste, such as peels, seeds and pulp; fortunately, the waste are rich in flavonoids, carotenoids, polyphenols, and limonoids compounds which all have excellent bioactivities [1- 10] and the development of these compounds could create additional value. The human hepatitis B virus (HBV) is a global disease that is especially prevalent in Asia and Africa. Infections could induce acute hepatitis that could cause the infected into chronic hepatitis carriers. Approximately one-quarter to one-third of those infected will develop early liver cirrhosis and are at elevated risk of hepatocellular carcinoma [11,12]. Current treatments include Interferon-α, Lamivudine, Adefovir, Entecavir, and Telbivudine, but these drugs can only reduce the activity or temporally inhibit the reproduction of HBV and cannot eradicate HBV from the human body. Therefore, in recent years, developing antivirus drugs from natural products has become an important research topic. Research has revealed that flavonoids in citrus demonstrated antivirus activities [13-17], but little research has been conducted on the anti-HBV properties of citrus. So far the only citrus anti-HBV research consisted of isolated imperatorin purified from pomelo (C. grandis (L.) Osbeck) peels, in which findings displayed that imperatorin possessed excellent inhibition effect on the surface antigen and e-antigen of HBV [18]. The purpose of this study is to investigate the anti-HBV activity of calamondin and citrus flanonoids. We used HBV transected cell line MS-G2 to assess that anti-HBV ability.
Relation:	Pharm Anal Acta
Appears in Collections:	[Department of Biological Science and Technology] Papers

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