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    Please use this identifier to cite or link to this item: http://ir.meiho.edu.tw/ir/handle/987654321/2573


    Title: A panel of tumor markers, calreticulin, annexin A2, and annexin A3 in upper tract urothelial carcinoma identified by proteomic and immunological analysis
    Authors: Chih-Ming Lu;Jen-Jie Lin;Han-Hsiang Huang;Ying-Chin Ko;Jue-Liang Hsu;Jiing-Chuan Chen;Zhong-Hao Din;Yu-Jen Wu
    Contributors: 健康暨護理學院
    Date: 2014
    Issue Date: 2014-10-17T03:10:20Z (UTC)
    Abstract: Background: Upper tract urothelial carcinoma (UTUC) is a tumor with sizable metastases and local recurrence. It
    has a worse prognosis than bladder cancer. This study was designed to investigate the urinary potential tumor
    markers of UTUC.
    Methods: Between January 2008 and January 2009, urine was sampled from 13 patients with UTUC and 20 healthy
    adults. The current study identified biomarkers for UTUC using non-fixed volume stepwise weak anion exchange
    chromatography for fractionation of urine protein prior to two-dimensional gel electrophoresis.
    Results: Fifty five differential proteins have been determined by comparing with the 2-DE maps of the urine of
    UTUC patients and those of healthy people. Western blotting analysis and immunohistochemistry of tumor tissues
    and normal tissues from patients with UTUC were carried out to further verify five possible UTUC biomarkers,
    including zinc-alpha-2-glycoprotein, calreticulin, annexin A2, annexin A3 and haptoglobin. The data of western blot
    and immunohistochemical analysis are consistent with the 2-DE data. Combined the experimental data in the urine
    and in tumor tissues collected from patients with UTUC, the crucial over-expressed proteins are calreticulin, annexin
    A2, and annexin A3.
    Conclusions: Calreticulin, annexin A2, and annexin A3 are very likely a panel of biomarkers with potential value for
    UTUC diagnosis.
    Relation: Lu et al. BMC Cancer
    Appears in Collections:[Department of Beauty Science] Papers

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