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    題名: Inhibition of Melanogenesis by Gallic Acid: Possible Involvement of the PI3K/Akt, MEK/ERK and Wnt/β-Catenin Signaling Pathways in B16F10 Cells
    作者: Tzu-Rong Su;Jen-Jie Lin;Chi-Chu Tsai;Tsu-Kei Huang;Zih-Yan Yang;Ming-O Wu;Yu-Qing Zheng;Ching-Chyuan Su;Yu-Jen Wu
    貢獻者: 健康暨護理學院
    日期: 2013
    上傳時間: 2014-10-17T03:33:25Z (UTC)
    摘要: Gallic acid is one of the major flavonoids found in plants. It acts as an antioxidant,
    and seems to have anti-inflammatory, anti-viral, and anti-cancer properties. In this study, we
    investigated the effects of gallic acid on melanogenesis, including the activation of
    melanogenesis signaling pathways. Gallic acid significantly inhibited both melanin synthesis
    and tyrosinase activity in a dose- and time-dependent manner, and decreased the expression
    of melanogenesis-related proteins, such as microphthalmia-associated transcription factor
    (MITF), tyrosinase, tyrosinase-related protein-1 (TRP1), and dopachrome tautomerase (Dct). In addition, gallic acid also acts by phosphorylating and activating melanogenesis
    inhibitory proteins such as Akt and mitogen-activated protein kinase (MEK)/extracellular
    signal-regulated kinase (ERK). Using inhibitors against PI3K/Akt (LY294002) or
    MEK/ERK-specific (PD98059), the hypopigmentation effect was suppressed, and the
    gallic acid-initiated activation of MEK/ERK and PI3K/Akt was also revoked. Gallic
    acid also increased GSK3β and p-β-catenin expression but down-regulated p-GSK3β.
    Moreover, GSK3β-specific inhibitor (SB216763) restored gallic acid-induced melanin
    reduction. These results suggest that activation of the MEK/ERK, PI3K/Akt, and inhibition
    of Wnt/β-catenin signaling pathways is involved in the melanogenesis signaling cascade,
    and that activation by gallic acid reduces melanin synthesis via down-regulation of MITF
    and its downstream signaling pathway. In conclusion, gallic acid may be a potentially
    agent for the treatment of certain skin conditions.
    關聯: International Journal of Molecular Sciences
    顯示於類別:[美容系] 期刊論文

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