Meiho University Institutional Repository:Item 987654321/2576
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    题名: The stimulatory effects of alpha1-adrenergic receptors on TGF-beta1, IGF-1 and hyaluronan production in human skin fibroblasts
    作者: Ming-Huei Liao;Shyh-Shyan Liu;I-Chin Peng;Feng-Jen Tsai;Han Hsiang Huang
    贡献者: 健康暨護理學院
    日期: 2014
    上传时间: 2014-10-17T03:48:20Z (UTC)
    摘要: Skin fibroblasts modulate tissue repair, wound
    healing and immunological responses. Adrenergic receptors
    (ARs) mediate important physiological functions, such as
    endocrine, metabolic and neuronal activity. In this study, the
    expression α1A-ARs in human skin fibroblasts is examined
    and verified. Regulatory effects of α1-agonist cirazoline on
    cell migration and the production of transforming growth
    factor β1 (TGF-β1), insulin-like growth factor 1 (IGF-1),
    hyaluronan (HA), fibronectin and procollagen type I
    carboxy-terminal peptide (PIP) by human skin fibroblasts
    are assessed and validated. α1A-AR mRNA and protein were
    found in human skin fibroblasts WS1. Exposure of cirazoline
    doubled skin fibroblast migration and the increase in cell
    migration was attenuated by α1-antagonist prazosin.
    TGF-β1 mRNA and production were enhanced after exposure to cirazoline and IGF-1 production was also increased
    after treatment with cirazoline. Exposure to cirazoline
    also enhanced HA and PIP production. The increases in
    TGF-β1, IGF-1, HA and PIP production were partially
    abolished in fibroblasts transfected with α1A-AR short interfering
    RNAs, indicating that α1A-ARs are involved in the
    cirazoline-induced increases in TGF-β1, IGF-1, HA and PIP
    production. Thus, α1A-ARs are stably expressed and stimulate
    cell migration and TGF-β1, IGF-1, HA and PIP production
    in human skin fibroblasts. Moreover, TGF-β1, IGF-1,
    HA and PIP production and the cell migration of human skin
    fibroblasts are possibly modulated by natural catecholamines
    produced by the endocrine system or sympathetic innervation,
    which could directly or indirectly participate in cytokine secretion,
    fibroblast migration and matrix production of wound
    healing in the skin.
    關聯: Cell Tissue Res
    显示于类别:[美容系] 期刊論文

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