Metabolic syndrome and C-reactive protein concentration asindependent correlates of chronic kidney disease

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Please use this identifier to cite or link to this item: http://ir.meiho.edu.tw/ir/handle/987654321/2791

Title:	Metabolic syndrome and C-reactive protein concentration asindependent correlates of chronic kidney disease
Authors:	Yang, Tsan;Chou, Yu-Ching;Chu, hi-Hong;Lin, hih-Hua;Hsieh, o-Chien
Keywords:	Chronic kidney disease;C-reactive protein
Date:	2015-08-19
Issue Date:	2015-08-24T07:24:51Z (UTC)
Abstract:	Inflammation is a common phenotype for cardiometabolic disorders. In this study, we attemptedto investigate inter-relationships between metabolic syndrome (MetS), C-reactive protein (aninflammatory biomarker) and chronic kidney disease (CKD). We performed a cross-sectionalanalysis of data from a representative sample of 4425 Chinese adults in Taiwan. The MetS wasdefined by a unified criteria set by several major organizations. A CKD event was defined as anestimated glomerular filtration rate (eGFR)560 mL/min per 1.73m2. Additionly, a CRP cutpoint of3 mg/L was used to differentiate high and low CRP levels. Overall, 1000 participants had MetS,resulting in a prevalence rate of 22.6%. High CRP level was noted in 782 (17.6%) subjects. Inaddition, a total of 508 (11.5%) persons qualified as having CKD. Subjects with the MetS had 1.55-fold [95% confidence interval (CI), 1.03–2.32] increased odds of CKD compared with theircounterparts without the MetS after multiple adjustments. In addition, there was a significantlygraded relationship between increasing levels of serum CRP and prevalent CKD (p fortrend?0.001). Participants in the highest category of serum CRP had a significantly elevatedodds of CKD as compared with those in the lowest category [odds ratio (OR), 1.60; 95% CI, 1.21–2.12]. However, there was no interaction in excess of additive scale between the presence of MetSand high CRP level (p?0.83). These findings suggest that MetS and high CRP wereindependently associated with increased prevalence of CKD in Chinese adults.
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