Meiho University Institutional Repository:Item 987654321/2802
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 2872/3785 (76%)
造訪人次 : 3426847      線上人數 : 71
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於MUIR ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.meiho.edu.tw/ir/handle/987654321/2802


    題名: Effects of Grifola frondosa non-polar bioactive components on high-fat diet fed and streptozotocin-inducedhyperglycemic mice
    作者: Shen, Kuo-Ping;Su, Chun-Han;Lu, Tzy-Ming;La, Min-Nan;Ng, Lean-Teik
    日期: 2015-09-14
    上傳時間: 2015-09-14
    摘要: Context: Consumption of medicinal mushrooms for disease prevention and maintaining healthhas a very long history in Asia. Grifola frondosa (Fr) S.F. Gray (GF) (Meripilaceae) is a medicinalfungus popularly used for enhancing immune systems, lowering blood glucose, and improvingspleen, stomach, and nerve functions.Objective: This study examines the hypoglycemic effects of GF in vitro and in vivo, and analyzesthe chemical profiles of its bioactive components.Materials and methods: In vitro hypoglycemic effects of GF was evaluated enzymaticallyusing a-amylase and a-glucosidase inhibition assays, whereas in vivo study was conducted onhigh-fat diet fed and streptozotocin (HFD + STZ)-induced hyperglycemic mice. GC-MS was usedto determine the chemical profiles of bioactive components.Results: The non-polar fraction of GF exhibited a stronger anti-a-glucosidase activity(IC50: 0.0332 mg/ml) than acarbose, but its anti-a-amylase activity (IC50: 0.671 mg/ml) wasweaker. Oral administration of GF at 600 mg/kg (GF600) significantly lowered the bloodglucose, HbA1c, average blood glucose, and serum total cholesterol levels in hyperglycemicmice. Although GF was found to contain mainly oleic acid and linoleic acid, their levels in thefungus were low, suggesting that the effects of GF on HFD + STZ-induced hyperglycemic micecould be due to factors other than these fatty acids.Conclusion: These results conclude that GF possesses anti-a-glucosidase activity, andhypoglycemic effect in HFD + STZ-induced hyperglycemic mice.
    顯示於類別:[護理系] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    護理系沈國屏-典藏.pdf223KbAdobe PDF0檢視/開啟


    檢視Licence

    在MUIR中所有的資料項目都受到原著作權保護.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋