Respiratory failure with mechanical ventilation of patients requiring reintubation after extubation failure have a higher incidence of hospital mortality. Therefore,this study was to find the possible risk of reintubation on those ventilator-dependent patients, expect that we may reduce the reintubation rate and elevated medical resource utilization. Patients aged older than 17 years old and required more than 3 weeks of mechanical ventilation support were selected. Here were total 375 cases include 287 successful weaning and 88 reintubation. Risk factors included their demographic features, acute physiology and chronic health evaluation (APACHE) II scoring system, Charlson Comorbidity Index (CCI) score, and sepsis; specifically as well as laboratory data. The two groups is statistically significant difference in APACH II, Ventilatory data, Biochemistry data, Hematologic data and CCI score analysis shows cardiovascular disease and malignancy to be the most important complications. Based on the logistic regression analysis result, factors leading to reintubation included age, 1st APACH II, hemoglobin, CCI score and sepsis were observed to be significant. Based on the results, we suggested that if clinical physician could avoid inpatients assossiated healthcare-associated infection (HAI) with sepsis occur and keep hemoglobin(Hb) of patients above 12.0 g/dL and respectively, the reintubation rate may be significantly reduced.
