| 摘要: | The spleen is a crucial organ in humans. However, little is known aboutthe association of venous thromboembolism (VTE) with splenic injuryand splenectomy in trauma patients. The aim of this study was to determinethe subsequent risk of VTE following splenic injury and splenectomy.A nationwide retrospective cohort study was conducted byanalysing data from the National Health Insurance Research Databasein Taiwan. We included 6,162 splenic injury patients (3,033 splenectomisedand 3,129 nonsplenectomised patients) and 24,648 comparisonpatients who were selected by frequency match based on sex, age,and the index year during 2000–2006. All patients were followed untilthe occurrence of VTE, 31 December, 2011, death, or withdrawal fromthe insurance program. The age of patients with splenic injury was41.93 ± 16.44 years. The incidence rates of VTE were 11.81, 8.46, and5.21 per 10,000 person-years in the splenic injury patients with splen -ectomy, splenic injury patients without splenectomy, and comparisonpatients, respectively. Compared with the comparison cohort, splenicinjury patients with splenectomy exhibited a 2.21-fold risk of VTE(95 % confidence interval [CI], 1.43–3.43), whereas those withoutsplenectomy exhibited a 1.71-fold risk of VTE (95 % CI, 1.05–2.80).The overall incidence rate of VTE was 1.97-fold higher in the splenicinjury cohort than the comparison cohort (95 % CI, 1.38–2.81). Althoughsplenectomy increased the risk of VTE 1.35-fold comparedwith no splenectomy, the difference was not statistically significant(95 % CI, 0.74–2.45). These results may alert physicians and patients to the complications of splenic injury and splenectomy. |
