海綿活性成分theonellasterol抑制口腔癌細胞存活之分子機制研究

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Title:	海綿活性成分theonellasterol抑制口腔癌細胞存活之分子機制研究
Authors:	吳裕仁
Date:	2015-05
Issue Date:	2016-05-11T06:09:08Z (UTC)
Abstract:	The anti-tumor effects of theonellasterol, an active ingredient isolated from Hippospongia sp, on CAL-27 cells were investigated in this study. In the MTT assay for cell proliferation, increasing concentrations of 11-dehydrosinulariolide decreased CAL-27 cell viability. When a concentration of 1.5 µg/mL of theonellasterol was applied, the CAL-27 cells viability was reduced to a level of 70% of the control sample. The wound healing function decreased as the concentration of theonellasterol increased. The results in this study indicated that treatment with theonellasterol for 6 h significantly induced both early and late apoptosis of CAL-27 cells, observed by flow cytometric measurement and microscopic fluorescent observation. The results of this study provided clues for the investigation of biochemical mechanisms of the anti-tumor effects of theonellasterol on CAL-27 cells and could be valuable information for drug development and progression monitoring of oral squamous cell carcinoma (OSCC).
Relation:	103年度教師產學合作計畫結案報告書
Appears in Collections:	[Department of Beauty Science] Research Projects

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