Abstract: This study investigated uric acid levels as a risk marker for chronic kidney disease (CKD).This cross-sectional study focused on the 9,450 persons who attended the free health check at a hospital in Kaohsiung, Taiwan between July 2005 and July 2011. CKD was divided into non-CKD, CKD stages 1-2, and CKD stages 3-5. The 2002 National Kidney Foundation kidney disease outcomes quality initiative (K/DOQI) was used as the standard for diagnosis. Multiple logistic regression analysis was used to examine the influence of uric acid levels on CKD. The ratio of advanced stage diagnoses increased as uric acid levels increased; the results for CKD stages 3-5 were more significant. Multiple logistic regression analysis indicated that in models 1, 2, and 3, as uric acid levels increased, the risk for CKD stages 1-2 and stages 3-5 increased. This increased risk was more significant for CKD stages 3-5.The amount of kidney damage caused by CKD increases as uric acid levels increase. While controlling all other risk factors, uric acid can be used as an independent predictor for CKD.
