Meiho University Institutional Repository:Item 987654321/3208
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 2872/3785 (76%)
造访人次 : 3428331      在线人数 : 578
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于MUIR ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.meiho.edu.tw/ir/handle/987654321/3208


    题名: Regulation of PACT-Mediated Protein Kinase Activation by theOV20.0 Protein of Orf Virus
    作者: Yeu-Yang Tseng,;Guan-Ru Liao,;Ganes C.Sen,;Lin, Fong-Yuan;Hsua, Wei-Li
    日期: 2016-09-08
    上传时间: 2016-10-17T08:19:11Z (UTC)
    摘要: Double-stranded RNA (dsRNA)-activated protein kinase (PKR), a major component of the cellular antiviral system, is activatedby the binding of either dsRNA or the cellular PKR activator, the PACT protein. The suppression of PKR activation is one of themain strategies that viruses employ to circumvent interferon signaling. Orf virus (ORFV), a parapoxvirus from the Poxviridaefamily, causes contagious pustular dermatitis in small ruminants. Previous studies have demonstrated that various OV20.0 isoforms,encoded by the OV20.0L gene, are able to inhibit PKR activation both by sequestering dsRNA and by physically interactingwith PKR in vitro. Thus, this gene acts as a virulence factor of ORFV when tested using a mouse infection model. In the presentstudy, the regions within OV20.0 that interact with dsRNA and with PKR have been mapped. Furthermore, this studydemonstrates for the first time that OV20.0 is also able to interact with the dsRNA binding domain of PACT and that the presenceof dsRNA strengthened the interaction of these two molecules. The presence of OV20.0 diminishes PKR phosphorylationwhen this is stimulated by PACT. Nevertheless, the association of OV20.0 with PKR, rather than with PACT, was found to beessential for reducing PACT-mediated PKR phosphorylation. These observations elucidate a new strategy whereby innate immunity
    can be evaded by ORFV
    显示于类别:[美容系] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    Regulation+of+PACT-Mediated+Protein+Kinase+Activation+by+the+OV20.0+Protein+of+Orf+Virus.pdf2051KbAdobe PDF2003检视/开启


    检视Licence

    在MUIR中所有的数据项都受到原著作权保护.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈