Meiho University Institutional Repository:Item 987654321/3534
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    题名: PGBR extract ameliorates TNF-a induced insulin
    作者: Chen, Fu-Chih;Shen, Kuo-Ping;Chen, Jin-Bor;Lin, Hui-Li;Hao, Chi-Long;Yen, Hsueh-Wei;Shaw, Shyh-Yu
    关键词: Pre-germinated;brown rice;Insulin;TNF-a;HepG2 cell
    日期: 2018-04-18
    上传时间: 2018-04-18T05:13:58Z (UTC)
    摘要: Pre-germinated brown rice (PGBR) could ameliorate metabolic syndrome, however,
    not much research estimates the effect of PGBR extract on insulin resistance. The aim of this
    study is to examine the effects of PGBR extract in TNF-a induced insulin resistance. HepG2
    cells, hepatocytes, were cultured in DMEM medium and added with 5 mM insulin or with insulin
    and 30 ng/ml TNF-a or with insulin, TNF-a and PGBR extract (50, 100, 300 mg/ml). The glucose
    levels of the medium were decreased by insulin, demonstrating insulin promoted glucose uptake
    into cell. However, TNF-a inhibited glucose uptake into cells treated with insulin. Moreover,
    insulin increased the protein expressions of AMP-activated protein kinase (AMPK), insulin
    receptor substrate-1 (IRS-1), phosphatidylinositol-3-kinase-a (PI3K-a), serine/threonine kinase
    PI3K-linked protein kinase B (Akt/PKB), glucose transporter-2 (GLUT-2), glucokinase (GCK),
    peroxisome proliferator activated receptor-a (PPAR-a) and PPAR-g. TNF-a activated p65 and
    MAPKs (JNK1/2 and ERK1/2) which worsened the expressions of AMPK, IRS-1, PI3K-a, Akt/
    PKB, GLUT-2, GCK, glycogen synthase kinase-3 (GSK-3), PPAR-a and PPAR-g. Once this relationship
    was established, we added PGBR extract to cell with insulin and TNF-a. We found glucose
    levels of medium were lowered and that the protein expressions of AMPK, IRS-1, PI3K-a, Akt/
    PKB, GLUT-2, GCK, GSK-3, PPAR-a, PPAR-g and p65, JNK1/2 were also recovered. In conclusion,
    this study found that TNF-a inhibited insulin stimulated glucose uptake and aggravated
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