Eugenosedin-A improves glucose metabolism andinhibits MAPKs expression in streptozotocin/nicotinamide-induced diabetic rats

Meiho University Institutional Repository > 健康暨護理學院 > 護理系 > 期刊論文 > Item 987654321/3535

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.meiho.edu.tw/ir/handle/987654321/3535

题名:	Eugenosedin-A improves glucose metabolism andinhibits MAPKs expression in streptozotocin/nicotinamide-induced diabetic rats
作者:	Shen, Kuo-Ping;Lin, Hui-Li;Yen, Hsueh-Wei;Hsieh, Su-Ling;An, Li-Mei;Wu, Bin-Nan
关键词:	Eugenosedin-A;Type II diabetes;mellitus;Insulin;Glucose metabolism;MAPKs pathway
日期:	2018-04-18
上传时间:	2018-04-18T05:36:40Z (UTC)
摘要:	This study examined the effects of eugenosedin-A (Eu-A) in a streptozotocin (STZ)/ nicotinamide-induced rat model of type II diabetes mellitus (T2DM). Six-week-old Spraguee Dawley rats were randomly divided into three groups: (1) RD group, normal rats fed a regular diet (RD), (2) DM group, T2DM rats fed a high-fat diet, and (3) Eu-A group, T2DM rats fed a high fat diet plus oral Eu-A (5 mg/kg/day). After 30 days, the DM group had higher body weight, higher blood glucose and lower insulin levels than the RD group. The DM group also had increased protein expression of glycogen synthase kinase (GSK) in liver and skeletal muscle and decreased protein expression of insulin receptor (IR), insulin receptor substrate-1 (IRS- 1), IRS-2, AMP-activated protein kinase (AMPK), glucose transporter-4 (GLUT-4), glucokinase (GCK), and peroxisome proliferator-activated receptor g (PPAR-g). STZ/nicotinamideinduced T2DM increased the expression of mitogen-activated protein kinases (MAPKs: p38, ERK, JNK) and inflammatory p65 protein. In the Eu-A treated T2DM rats, however, blood
显示于类别:	[護理系] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
沈國屏2018-KJMS (Eu-A).pdf		645Kb	Adobe PDF	1	检视/开启

检视Licence

在MUIR中所有的数据项都受到原著作权保护.