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| 題名: | Secoiridoids from the Seed of Gonocaryum calleryanum and Their Inhibitory Potential on LPS-Induced Tumor Necrosis Factor and Nitric Oxide Production |
| 作者: | Cheng, Kun-Ching;Chang, Chi-I;Lin, Yu-Chi;Liu, Chih-I;Zeng, Yu-Ci;Lin, Yun-Sheng |
| 關鍵詞: | Gonocaryum calleryanum;secoiridoid;structure identification;anti-inflammatory |
| 日期: | 2018-10-03 |
| 上傳時間: | 2018-10-09 |
| 摘要: | Abstract: Three new secoiridoid constituents, goncarin A–C (1–3), and a new derivative, goncarin A
monoacetate (4), along with two known lignins, pinoresinol (5) and paulownin (6), were isolated
from the seed of Gonocaryum calleryanum (Baill.) Becc. The structures of the new metabolites were
determined on the basis of extensive spectroscopic analysis, particularly mass spectroscopy and
2D NMR (1H–1H COSY, HMQC, HMBC, and NOESY) spectroscopy. The aim of this study was to
identify the anti-inflammatory effects of compounds 1–6 on lipopolysaccharide (LPS)-stimulated
murine macrophage cell lines (RAW 264.7). Following stimulation with LPS, elevated levels
of nitric oxide (NO) production were detected in RAW 264.7 cells; however, pretreatment with
compounds 1–6 significantly inhibited the production of NO (around 40–80%, p < 0.01–0.05),
by suppressing the expression of inducible NO synthase (iNOS). In addition, LPS-stimulated
tumor necrosis factor-_ (TNF-_) production was significantly reduced by compounds 1–3 (25–40%,
p < 0.01–0.05). These results suggested that compounds 1–3 may exert anti-inflammatory activity,
and that compounds 1–3 may be considered a potential therapeutic for the treatment of inflammatory
diseases associated with macrophage activation. |
| 顯示於類別: | [生物科技系] 期刊論文
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