Meiho University Institutional Repository:Item 987654321/369
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    MUIR > Journal of Meiho University > n.12(1994/08) >  Item 987654321/369


    Please use this identifier to cite or link to this item: http://ir.meiho.edu.tw/ir/handle/987654321/369


    Title: 先天性糖尿病鼠血漿胃抑素及胰島素
    Authors: 沈賈堯
    Date: 1994-08
    Issue Date: 2011-03-05T08:19:08Z (UTC)
    Abstract: 本文旨在研究先天性糖尿病鼠以雌雄分組,各配合BB,Wistar(WS)及Sprague-Dawley(SD)三種系之正常鼠作為對照。所有實驗動物經右頸靜脈插管手術後,休息一夜;隔天清晨禁食2~4小時候開始餵實驗動物口服葡萄糖液(40%,3.2g/kg BW)。口服葡萄糖前10分鐘即口服葡萄糖後0,10,20,30,45,60及90分鐘各進行每次0.5毫升的採血;其中血糖濃度由葡萄糖分析儀(YSI,Model23A)測定,血漿胃抑素及胰島素濃度則由放射免疫分析法測定。先天性糖尿病鼠的血糖濃度餘口服葡萄糖前後皆明顯高於正常鼠,而血漿胰島素濃度餘口服葡萄糖前後則明顯低於正常鼠。雄性糖尿病鼠血漿胃抑素濃度於口服葡萄糖後20分鐘時高於之正常BB雄鼠,雌性糖尿病鼠血漿胃抑素濃度於口服葡萄糖後10到20分鐘時高於正常BB雌鼠;各種系之正常雄鼠間血漿胃抑素濃度的變化並無明顯差異。SD雌鼠口服葡萄糖後血漿胃抑素濃度分別高於正常BB雌鼠,WS雌鼠及雌性糖尿病鼠,而WS雌鼠者又高於政持BB雌鼠。以上實驗結果顯示,BB種系糖尿病鼠血漿胃抑素對口服葡萄糖刺激之反應比BB種系正常鼠強,而且血漿胃抑素濃度的變化並具有種系及性別上的之差異。
    Appears in Collections:[Journal of Meiho University] n.12(1994/08)

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