| 摘要: | This study examined the effect of pre‐germinated brown rice extract (PGBRE), containing
no dietary fibers, but γ‐oryzanol, γ‐aminobutyric acid (GABA), flavonoids, and
anthocyanidin, on high‐fat‐diet (HFD)‐induced metabolic syndrome. C57BL/6 mice
were divided into five groups: regular diet, HFD, HFD with oral PGBRE 30, 300, or
600 mg/kg per day for 18 weeks. In the HFD group, higher body and liver weight gain,
hyperglycemia, HbA1c, and insulin; higher TG, TC, LDL‐C, non‐HDL, atherosclerosis
index, lower HDL, adiponectin in blood; higher TG in the liver; higher TG, bile acid in
feces; and lower protein levels of AMP‐activated protein kinase, insulin receptor, insulin
receptor substrate‐1, insulin receptor substrate‐2, peroxisome proliferator‐activated
receptor‐γ, phosphatidylinositol‐3‐kinase, Akt/PKB, glucose transporter‐1, glucose
transporter‐4, glucokinase in the skeletal muscle; lower glucagon‐like peptide 1 (GLP‐1)
in the intestine; higher sterol regulatory element‐binding protein‐1 (SREBP‐1), stearoyl‐
CoA desaturase 1 (SCD‐1), fatty acid synthase (FAS), 3‐hydroxy‐3‐methylglutaryl‐CoA
reductase, proprotein convertase subtilisin/kexin type 9 (PCSK9), and lower PPAR‐α,
low‐density lipoprotein receptor, cholesterol‐7α‐hydroxylase in the liver; higher
SREBP‐1, SCD‐1, FAS, and lower PPAR‐α, adiponectin in the adipose tissue were found.
In HFD + PGBRE groups, the above biochemical parameters were improved. |
