Meiho University Institutional Repository:Item 987654321/3729
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    题名: Genomic Features, Comparative Genomic Analysis,
    作者: Liang, Chih-Yu;Yang, Chih-Hui;Lai, Chung-Hsu;Huang, Yi-Han;Lin, Jiun-Nong
    关键词: Chryseobacterium arthrosphaerae;genomic features;comparative genomics;antimicrobial
    日期: 2019-09-02
    上传时间: 2019-09-02T05:56:27Z (UTC)
    摘要: Abstract: Bacteria belonging to the genus Chryseobacterium are ubiquitously distributed in natural
    environments, plants, and animals. Except C. indologenes and C. gleum, other Chryseobacterium
    species rarely cause human diseases. This study reported the whole-genome features, comparative
    genomic analysis, and antimicrobial susceptibility patterns of C. arthrosphaerae ED882-96 isolated
    in Taiwan. Strain ED882-96 was collected from the blood of a patient who had alcoholic liver
    cirrhosis and was an intravenous drug abuser. This isolate was initially identified as C. indologenes
    by using matrix-assisted laser desorption ionization–time of flight mass spectrometry. The analysis
    of 16S ribosomal RNA gene sequence revealed that ED882-96 shared 100% sequence identity with
    C. arthrosphaerae type strain CC-VM-7T. The results of whole-genome sequencing of ED882-96
    showed two chromosome contigs and one plasmid. The total lengths of the draft genomes of
    chromosome and plasmid were 4,249,864 bp and 435,667 bp, respectively. The findings of both in silico
    DNA–DNA hybridization and average nucleotide identity analyses clearly demonstrated that strain
    ED882-96 was a species of C. arthrosphaerae. A total of 83 potential virulence factor homologs were
    predicted in the whole-genome sequencing of strain ED882-96. This isolate was resistant to all tested
    antibiotics, including _-lactams, _-lactam/_-lactamase inhibitor combinations, aminoglycosides,
    fluoroquinolones, tetracycline, glycylcycline, and trimethoprim-sulfamethoxazole. Only one antibiotic
    resistance gene was recognized in the plasmid. By contrast, many antibiotic resistance genes were
    identified in the chromosome. The findings of this study suggest that strain ED882-96 is a highly
    virulent and multidrug-resistant pathogen. Knowledge regarding genomic characteristics and
    antimicrobial susceptibility patterns provides valuable insights into this uncommon species.
    显示于类别:[生物科技系] 期刊論文

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