New secondary metabolite with cytotoxicity from spawning soft coral Asterospicularia laurae in Taiwan

MUIR > Graduate Institute of Health Care > Department of Biological Science and Technology > Papers > Item 987654321/3750

Please use this identifier to cite or link to this item: http://ir.meiho.edu.tw/ir/handle/987654321/3750

Title:	New secondary metabolite with cytotoxicity from spawning soft coral Asterospicularia laurae in Taiwan
Authors:	Su, Jui-Hsin;Liu, Chih-I;Lu, Mei-Chin;Chang, Chi-I;Hsieh, Min-Ying;Yu-Chi Lin
Keywords:	Asterospicularia laurae;coral;spawning;xenicane;diterpenoid;cytotoxicity
Date:	2019-09-16
Issue Date:	2019-10-16T08:49:17Z (UTC)
Abstract:	We have conducted a long-term research on the Taiwanese soft coral Asterospicularia laurae, which resulted in many xenicanetype diterpenoids such as asterolaurins A–M from A. laurae coral tissues during the non-spawning period were isolated. Here, we report a new xenicane diterpenoid, asterolaurin N (1), along with three known xenicane-type monocarbocyclic diterpenes [13-epi- 9-desacetylxenicin (2), xeniolide-B 9-acetate (3) and asterolaurin I (4)] from A. laurae during the spawning period. The structures of the new secondary metabolite were established with an extensive spectroscopic analysis. The 1D and 2D nuclear magnetic resonance (NMR) data of the compounds were discussed. We discovered that the C-15 of 1 contains two methyl groups on a carbon bearing an acetyl group, which has not been reported previously. In addition, Compounds 1, 3, and 4 showed selective cytotoxic activity against Molt 4, while 2 exhibited significant cytotoxicity against Molt 4, K562, Sup-T1 and U937 cell lines.
Appears in Collections:	[Department of Biological Science and Technology] Papers

Files in This Item:

File	Description	Size	Format
林昀生期刊內容 (2).pdf		1006Kb	Adobe PDF	1	View/Open

View Licence