Extract of pre-germinated brown rice protects against cardiovascular dysfunction by reducing levels of inflammation and free radicals in a rat model of type II diabetes

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题名:	Extract of pre-germinated brown rice protects against cardiovascular dysfunction by reducing levels of inflammation and free radicals in a rat model of type II diabetes
作者:	Liang, Hsin-Li Cheng, Pei-Wen Lin, Hui-Li Hao, Chi-Long Ke, Liang-Yin Chou, Huei-Yin Tseng, Yu-Hsiu Yen, Hsueh-Wei Shen, Kuo-Ping
贡献者:	健康暨護理學院
关键词:	Metabolic syndrome Cardiovascular complications Extract of pre-germinated brown rice SHR T2DM
日期:	2020-09
上传时间:	2020-12-21T06:32:11Z (UTC)
摘要:	The aim of this study was to examine the effect of extract of pre-germinated brown rice (EP) on metabolic and cardiovascular dysfunction in a rat model of T2DM. Hypertensive rats were divided into: (1) normal diet (ND group), (2) induced T2DM (DM group), and T2DM rats that were treated with (3) EP30 mg/kg (EP30 group) or (4) EP300 mg/kg (EP300 group) per day for 4 weeks. T2DM symptoms included: weight loss, hyperglycaemia, hypoinsulinemia, hyperlipidaemia, higher HbA1c, glucose in urine, and lower GLP-1. EP treatment improved metabolic parameters, activated insulin signalling, and increased lipid metabolism, and also ameliorated T2DMassociated increases in levels of inflammation, free radicals, cardiac hypertrophy and fibrosis. EP reduced T2DM and related cardiovascular complications by increasing insulin signalling and lipid metabolism, and reducing levels of inflammation and free radicals. Thus, EP may be a potential candidate for the treatment of metabolic syndrome and related cardiovascular complications.
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