Link between Interleukin-10 Level and Outcome after Ischemic Stroke

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题名:	Link between Interleukin-10 Level and Outcome after Ischemic Stroke
作者:	Li-Teh Chang;Chun-Man Yuen;Chia-Wei Liou;Cheng-Hsien Lu;Wen-Neng Chang;Ali A. Youssef;Hon-Kan Yip
关键词:	Acute coronary syndromes;Cardiovascular diseases;Cerebrovascular diseases;Interleukin-10;Ischemic stroke;Stroke outcome
日期:	2009-06
上传时间:	2011-09-05T01:08:26Z (UTC)
摘要:	Objectives:The prognostic value of interleukin (IL)-10 in patients after acute ischemic stroke (IS) is not well understood. This study tested the hypothesis that serum levels of IL-10 are substantially increased after IS and predictive of IS outcome. Methods: Serum IL-10 levels were examined 48 h after acute IS in 135 consecutive patients, and in 20 healthy and 30 at-risk controls. Results: Mean serum IL-10 was significantly higher in IS patients than in both control groups (p ! 0.0001, respectively). Additionally, serum IL-10 was significantly higher in patients with severe neurological impairment [defined as a score 6 12 on the National Institute of Health Stroke Scale (NIHSS)] than in patients with less severe neurological impairment (NIHSS score ! 12) 48 h after IS (p ! 0.0001). Furthermore, higher serum IL-10 was strongly and independently correlated with severe neurological impairment (NIHSS 6 12) 48 h after acute IS (p ! 0.0001), and independently predictive of combined major adverse clinical outcomes (defined as recurrent IS, any cause of death or NIHSS 6 12) on day 90 following IS (p ! 0.0001). Conclusions: Serum IL-10 is an independent prognosticator of IS Outcome.
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