Pre-germinated brown rice prevented high-fat diet induced hyperpidemia through ameliorating lipid synthesis metabolism in C57BL/6J mice

MUIR > Graduate Institute of Health Care > Department of Food Science and Nutrition > Papers > Item 987654321/3159

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Title:	Pre-germinated brown rice prevented high-fat diet induced hyperpidemia through ameliorating lipid synthesis metabolism in C57BL/6J mice
Authors:	Kuo-Ping Shen;Chi-Long Hao;Hsueh-Wei Yen;Chun-Yen Chen;Jia-Hao Chen;Fu-Chih Chen;Hui-Li Lin
Keywords:	hyperlipidemia;lipid synthesis and metabolism;pre-germinated brown rice
Date:	2016
Issue Date:	2016-09-22
Abstract:	Pre-germinated brown rice (PGBR) can ameliorate hyperlipidemia, but the action mechanism is not clear. We focus the mechanisms of PGBR prevented hyperlipidemia. Six-week-old mice were divided into: standard-regular diet (SRD), high-fat diet (HFD) and HFD with PGBR (HFD + PGBR) groups for 16 weeks. The HFD group has higher concentrations of TG, TC, HDL and Non-HDL in the blood, and a higher atherosclerosis index (AI). The TG levels in the liver, and TG, bile acid levels in the feces were enhanced; and the total adipocytokines level in adipose tissue was reduced. The HFD group had higher protein expressions of SREBP-1, SCD-1, FAS, LDLR, and CYP7α1 in the liver. Moreover, the greater expressions of SREBP-1, SCD-1, FAS and the less expressions of PPAR-α and adiponectin were in adipose tissue. In the HFD + PGBR group, the PGBR regulated the levels of TG, TC, HDL, Non-HDL, AI and adipocytokines. PGBR increased more cholesterol and bile acid exhaust in feces. The SREBP-1, SCD-1, FAS, HMGCR, LDLR, CYP7α1 and PPAR-α proteins in the liver; and the SREBP-1, SCD-1, FAS, PPAR-α and adiponectin proteins in adipose tissue were reversed by PGBR. Taken together, PGBR can improve lipid synthesis and metabolism, and we suggest PGBR is a recommendable food for controlling hyperlipidemia.
Relation:	J Clin Biochem Nutr. 2016 Jul;59(1):39-44. doi: 10.3164/jcbn.15-117. Epub 2016 May 21.
Appears in Collections:	[Department of Food Science and Nutrition] Papers

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