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    题名: Genomic Features, Comparative Genomics, and Antimicrobial Susceptibility Patterns of Elizabethkingia bruuniana
    作者: Lin, Jiun-Nong
    Lai, Chung-Hsu
    Yang, Chih-Hui
    Huang, Yi-Han
    Lin, Hsi-Hsun
    贡献者: 健康暨護理學院
    日期: 2019-02
    上传时间: 2020-05-19T06:37:28Z (UTC)
    摘要: Elizabethkingia bruuniana is a novel species of the Elizabethkingia genus. There is scant information
    on this microorganism. Here, we report the whole-genome features and antimicrobial susceptibility
    patterns of E. bruuniana strain EM798-26. Elizabethkingia strain EM798-26 was initially identified as E.
    miricola. This isolate contained a circular genome of 4,393,011 bp. The whole-genome sequence-based
    phylogeny revealed that Elizabethkingia strain EM798-26 was in the same group of the type strain
    E. bruuniana G0146T. Both in silico DNA-DNA hybridization and average nucleotide identity analysis
    clearly demonstrated that Elizabethkingia strain EM798-26 was a species of E. bruuniana. The pangenome
    analysis identified 2,875 gene families in the core genome and 5,199 gene families in the pan
    genome of eight publicly available E. bruuniana genome sequences. The unique genes accounted for
    0.2–12.1% of the pan genome in each E. bruuniana. A total of 59 potential virulence factor homologs
    were predicted in the whole-genome of E. bruuniana strain EM798–26. This isolate was nonsusceptible
    to multiple antibiotics, but susceptible to aminoglycosides, minocycline, and levofloxacin. The wholegenome
    sequence analysis of E. bruuniana EM798-26 revealed 29 homologs of antibiotic resistancerelated
    genes. This study presents the genomic features of E. bruuniana. Knowledge of the genomic
    characteristics provides valuable insights into a novel species.
    显示于类别:[生物科技系] 期刊論文

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