Potential natural products that target the SARS-CoV-2 spike protein identified by structure-based virtual screening, isothermal titration calorimetry and lentivirus particles pseudotyped (Vpp) infection assay

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Title:	Potential natural products that target the SARS-CoV-2 spike protein identified by structure-based virtual screening, isothermal titration calorimetry and lentivirus particles pseudotyped (Vpp) infection assay
Authors:	Guan-Yu Chen;Yi-Cheng Pan;Tung-Ying Wu;Tsung-You Yao;, Wei-Jan Wang;Wan-Jou Shen;Azaj Ahmed;Shu-Ting Chan;Chih-Hsin Tang;Wei-Chien Huang;Mien-Chie Hung;Juan-Cheng Yang;Yang-Chang Wu
Contributors:	健康暨護理學院
Date:	2021-09
Issue Date:	2023-02-24T06:03:25Z (UTC)
Abstract:	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters cells through the binding of the viral spike protein with human angiotensin-converting enzyme 2 (ACE2), resulting in the development of coronavirus disease 2019 (COVID-19). To date, few antiviral drugs are available that can effectively block viral infection. This study aimed to identify potential natural products from Taiwan Database of Extracts and Compounds (TDEC) that may prevent the binding of viral spike proteins with human ACE2 proteins.
Appears in Collections:	[Department of Food Science and Nutrition] Papers

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