Exopolysaccharide activities from probiotic bifidobacterium: Immunomodulatory effects (on J774A.1 macrophages) and antimicrobial properties

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题名:	Exopolysaccharide activities from probiotic bifidobacterium: Immunomodulatory effects (on J774A.1 macrophages) and antimicrobial properties
作者:	Ming-Hsiu Wu;Tzu-Ming Pan;Yu-Jen Wu;Sue-Joan Chang;Ming-Song Chang;Chun-Yi Hu
贡献者:	Department of Nutrition and Health Science, Fooyin University, Kaohsiung County, Taiwan;Institute of Microbiology and Biochemistry, National Taiwan University, Taipei, Taiwan;Department of Beauty Science, Meiho Institute of Technology, Pingtung County, Taiwan;Department of Biology and Institute of Biodiversity, National Cheng Kung University, Tainan, Taiwan;Department of Surgery, Fooyin Hospital, Pingtung County, Taiwan;Research and Certificate Center of Health Food, Fooyin University, Kaohsiung County, Taiwan
关键词:	Probiotics;Exopolysaccharide (EPS);Cytokine;Macrophage;Antimicrobial test
日期:	2010-11
上传时间:	2011-09-28T04:06:58Z (UTC)
摘要:	Exopolysaccharides (EPSs) are a metabolite of probiotics which have gained wide interest recently, but little is known about their function. EPS was isolated from Bifidobacterium longum BCRC 14634 and sterilized by 0.22 μm filter. The proliferation of J77A.1 macrophages and their secretion of the anti-inflammatory cytokine interleukin-10 (IL-10) was elevated after treatment with heat-killed B. longum or 5 μg/mL EPS. The endotoxin, lipopolysaccharides (LPS), a potent inducer of pro-inflammatory cytokine tumor necrosis factor-α (TNF-α), significantly suppressed the growth of J77A.1 cells, and induced the secretion of TNF-α from J774A.1 cells. Furthermore, 24h pretreatment with 5 μg/ml EPS suppressed 100 ng/ml LPS-induced cell growth inhibition and release of TNF-α from J774A.1 cells. Additional experiments showed that 80 μg/mL EPS had antimicrobial activity against 7 species of food-spoilage and infection bacteria. Our results suggest that EPS from B. longum might be useful as a mild immune modulator for macrophages, contributing to the capacity of B. longum to fight against gastrointestinal infections, and even some food-spoilage microbe.
關聯:	Int J Food Microbiol. 2010 Nov 15;144(1):104-10. Epub 2010 Sep 15.
显示于类别:	[美容系] 期刊論文

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