Background Thyroid orbitopathy (TO) is a multi-system inflammatory
disease characterized by orbital congestion, ocular
surface disorders, restrictive myopathy, and skin lesions.
The molecular and cellular processes of pathogenic formation
of TO orbital fat tissues are not fully understood. In this study,
a comparative proteomic analysis was conducted to investigate
the importance of some differential proteins of orbital fat
tissues in TO.
Methods The differential proteins were analyzed by comparing
the two-dimensional gel electrophoresis (2-DE) maps of
the orbital fat tissues of TO with those of normal orbital fat
tissues. The 2-DE results were further verified byWestern blot
and immunohistochemistry.
