Risk of Nephrotic Syndrome following Enteroviral Infection in Children: A Nationwide Retrospective Cohort Study

MUIR > General Education Center > Papers > Item 987654321/3138

Please use this identifier to cite or link to this item: http://ir.meiho.edu.tw/ir/handle/987654321/3138

Title:	Risk of Nephrotic Syndrome following Enteroviral Infection in Children: A Nationwide Retrospective Cohort Study
Authors:	Jiun-Nong Lin;Cheng-Li Lin;Chi-Hui Yang;Ming-Chia Lin;Chung-Hsu Lai;Hsi-Hsun Lin;Chia-Hung Kao
Date:	2016
Issue Date:	2016-09-06T01:14:49Z (UTC)
Abstract:	Purpose Nephrotic syndrome is a common chronic illness encountered during childhood. Infections have been identified as a cause of nephrotic syndrome. The aim of this study was to evaluate the association between enteroviral infection and nephrotic syndrome. Methods A nationwide retrospective cohort study was conducted by analyzing data from the National Health Insurance Research Database in Taiwan. Children aged <18 years with enteroviral infection were enrolled. Non-enterovirus-infected children were randomly selected as the comparison cohort. The primary endpoint was the occurrence of nephrotic syndrome. Methods This study included 280,087 enterovirus-infected children and 280,085 non-enterovirusinfected children. The mean age of the enterovirus-infected children was 2.38 years, and 53.7%of these children were boys. The overall incidence densities of nephrotic syndrome for enterovirus- and non-enterovirus-infected children were 2.65 and 2.21 per 10,000 personyears, respectively. The enterovirus-infected cohort had a higher cumulative incidence of nephrotic syndrome than did the non-enterovirus-infected cohort (log-rank test, p = 0.01). Multivariable analyses revealed that children with enteroviral infection were significantly associated with an increased risk of nephrotic syndrome compared with those without enteroviral infection (adjusted hazard ratio, 1.20; 95%confidence interval, 1.04–1.39; p = 0.01), particularly in children infected with coxsackievirus. Subgroup analyses revealed that enterovirus-infected girls, children of blue-collar workers, and children without allergies had a higher risk of nephrotic syndrome than did children in the non-enterovirus-infected cohort. Conclusion This study revealed a significant association between enteroviral infection and nephrotic syndrome. Additional studies elucidating the role and pathogenesis of enterovirus in nephrotic syndrome are warranted.
Relation:	PLOS ONE \| DOI:10.1371/journal.pone.0161004 August 10, 2016
Appears in Collections:	[General Education Center] Papers

Files in This Item:

File	Description	Size	Format
105楊致慧期刊原文(PlosOne).PDF	fulltext	274Kb	Adobe PDF	0	View/Open

View Licence

Loading...