Meiho University Institutional Repository:Item 987654321/3138
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    题名: Risk of Nephrotic Syndrome following Enteroviral Infection in Children: A Nationwide Retrospective Cohort Study
    作者: Jiun-Nong Lin;Cheng-Li Lin;Chi-Hui Yang;Ming-Chia Lin;Chung-Hsu Lai;Hsi-Hsun Lin;Chia-Hung Kao
    日期: 2016
    上传时间: 2016-09-06T01:14:49Z (UTC)
    摘要: Purpose
    Nephrotic syndrome is a common chronic illness encountered during childhood. Infections have been identified as a cause of nephrotic syndrome. The aim of this study was to evaluate the association between enteroviral infection and nephrotic syndrome.
    Methods
    A nationwide retrospective cohort study was conducted by analyzing data from the National Health Insurance Research Database in Taiwan. Children aged <18 years with enteroviral infection were enrolled. Non-enterovirus-infected children were randomly selected as the comparison cohort. The primary endpoint was the occurrence of nephrotic syndrome.
    Methods
    This study included 280,087 enterovirus-infected children and 280,085 non-enterovirusinfected children. The mean age of the enterovirus-infected children was 2.38 years, and 53.7%of these children were boys. The overall incidence densities of nephrotic syndrome for enterovirus- and non-enterovirus-infected children were 2.65 and 2.21 per 10,000 personyears, respectively. The enterovirus-infected cohort had a higher cumulative incidence of nephrotic syndrome than did the non-enterovirus-infected cohort (log-rank test, p = 0.01).
    Multivariable analyses revealed that children with enteroviral infection were significantly associated with an increased risk of nephrotic syndrome compared with those without enteroviral infection (adjusted hazard ratio, 1.20; 95%confidence interval, 1.04–1.39; p = 0.01), particularly in children infected with coxsackievirus. Subgroup analyses revealed that enterovirus-infected girls, children of blue-collar workers, and children without allergies had a higher risk of nephrotic syndrome than did children in the non-enterovirus-infected cohort.
    Conclusion
    This study revealed a significant association between enteroviral infection and nephrotic syndrome. Additional studies elucidating the role and pathogenesis of enterovirus in nephrotic syndrome are warranted.
    關聯: PLOS ONE | DOI:10.1371/journal.pone.0161004 August 10, 2016
    显示于类别:[通識教育中心] 期刊論文

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