A Norsesterterpene Peroxide from a Marine Sponge Hippospongia sp.

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Title:	A Norsesterterpene Peroxide from a Marine Sponge Hippospongia sp.
Authors:	Ching-Chyuan Sua;Huey-Jen Su;Kai-Ju Liang;Su-June Tsai;Jui-Hsin Su
Keywords:	norsesterterpene peroxide;Hippospongia
Date:	2016
Issue Date:	2016-09-14T05:25:03Z (UTC)
Abstract:	One new norsesterterpene peroxide, rhopaloic acid H (1), along with two known related metabolites 2 and 3, were isolated from a marine sponge Hippospongia sp. The structures of compounds were elucidated by means of IR, MS, and NMR techniques and comparison of the NMR data with those of known analogues. Evaluation of the cytotoxicities revealed that compound 2 exhibited significant cytotoxicity against DLD-1, Molt 4, T47D and K-562 cell lines, with IC50 values of 3.18, 0.69, 2.22 and 1.06 μg/mL, respectively. Moreover, compound 3 also showed significant K562 inhibitory activity, with IC50 value of 3.65 μg/mL.
Relation:	Natural Product Communications 2016 Vol. 11 No. 4 445-446
Appears in Collections:	[Department of Nursing] Papers

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