A Norsesterterpene Peroxide from a Marine Sponge Hippospongia sp.

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题名:	A Norsesterterpene Peroxide from a Marine Sponge Hippospongia sp.
作者:	Ching-Chyuan Sua;Huey-Jen Su;Kai-Ju Liang;Su-June Tsai;Jui-Hsin Su
关键词:	norsesterterpene peroxide;Hippospongia
日期:	2016
上传时间:	2016-09-14T05:25:03Z (UTC)
摘要:	One new norsesterterpene peroxide, rhopaloic acid H (1), along with two known related metabolites 2 and 3, were isolated from a marine sponge Hippospongia sp. The structures of compounds were elucidated by means of IR, MS, and NMR techniques and comparison of the NMR data with those of known analogues. Evaluation of the cytotoxicities revealed that compound 2 exhibited significant cytotoxicity against DLD-1, Molt 4, T47D and K-562 cell lines, with IC50 values of 3.18, 0.69, 2.22 and 1.06 μg/mL, respectively. Moreover, compound 3 also showed significant K562 inhibitory activity, with IC50 value of 3.65 μg/mL.
關聯:	Natural Product Communications 2016 Vol. 11 No. 4 445-446
显示于类别:	[護理系] 期刊論文

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