Efficiency comparison of PGBR extract and γ-oryzanol in antioxidative stress and anti-inflammatory properties against metabolic syndrome

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题名:	Efficiency comparison of PGBR extract and γ-oryzanol in antioxidative stress and anti-inflammatory properties against metabolic syndrome
作者:	Ke, Hui-Li Lin；Shih-Hsiung Lin；Kuo-Ping Shen；Hua-Chen Chan； Yu-Hsiu Tseng；Hsueh-Wei Yen；Shi-Hui Law；Liang-Yin
贡献者:	健康暨護理學院
关键词:	inflammation metabolic syndrome oxidative stress pregerminated brown rice γ-oryzanol
日期:	2019-12
上传时间:	2020-09-01T02:27:17Z (UTC)
摘要:	This research aims to delineate the anti-inflammatory effect of pregerminated brown rice extract (PE) and γ-oryzanol on improving metabolic features of high-fat diet (HFD)-induced metabolic syndrome (MetS) mouse model. C57BL/6 mice were randomly divided into eight groups: regular diet (RD), HFD, HFD-combined treatment of 0.5, 5, or 10 mg kg−1 day−1 oral gavage γ-oryzanol, and 30, 300, or 600 mg kg−1 day−1 PE for 18 weeks. HFD-fed mice showed overweight, hyperglycemia, hyperlipidemia signs of metabolic disorder, and elevation of inflammatory cytokines such as IL-6, TNF-α, IFN-γ, NO, PGE2 in serum and MAPKs, transcription factor p65, iNOS, and MDA in the liver. In contrast, HFD-fed mice showed lower levels of adiponectin in serum and antiperoxidation enzymes GPx, SOD, and catalase in the liver. While HFDfed mice cotreated with PE or γ-oryzanol, HFD-induced metabolic disorders, ROS, and inflammation were improved. The anti-MetS, antioxidative stress and anti-inflammation properties of PE were more potent than γ-oryzanol.
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