| 摘要: | This research aims to delineate the anti-inflammatory effect of pregerminated brown
rice extract (PE) and γ-oryzanol on improving metabolic features of high-fat diet
(HFD)-induced metabolic syndrome (MetS) mouse model. C57BL/6 mice were randomly
divided into eight groups: regular diet (RD), HFD, HFD-combined treatment of
0.5, 5, or 10 mg kg−1 day−1 oral gavage γ-oryzanol, and 30, 300, or 600 mg kg−1 day−1
PE for 18 weeks. HFD-fed mice showed overweight, hyperglycemia, hyperlipidemia
signs of metabolic disorder, and elevation of inflammatory cytokines such as IL-6,
TNF-α, IFN-γ, NO, PGE2 in serum and MAPKs, transcription factor p65, iNOS, and
MDA in the liver. In contrast, HFD-fed mice showed lower levels of adiponectin in
serum and antiperoxidation enzymes GPx, SOD, and catalase in the liver. While HFDfed
mice cotreated with PE or γ-oryzanol, HFD-induced metabolic disorders, ROS,
and inflammation were improved. The anti-MetS, antioxidative stress and anti-inflammation
properties of PE were more potent than γ-oryzanol. |
